The Sinclair Method Guide Blog

In-depth articles on the Sinclair Method, naltrexone, alcohol science, and what the research actually says about medication-assisted alcohol reduction.

What Is Gray-Area Drinking — and Why Does It Matter?

Millions of people drink too much without fitting the traditional picture of 'alcoholism.' Here's what gray-area drinking actually means, and what options exist.

Read article

Alcohol & BehaviorFeatured

What Is Gray-Area Drinking — and Why Does It Matter?

Millions of people drink too much without fitting the traditional picture of 'alcoholism.' Here's what gray-area drinking actually means, and what options exist.

9 min readApril 14, 2025

NaltrexoneFeatured

Naltrexone vs. Antabuse: What's the Difference?

Two very different medications for alcohol use disorder — one blocks reward, one punishes drinking. Here's how they compare.

8 min readApril 7, 2025

Getting StartedFeatured

How to Talk to Your Doctor About Naltrexone

Many clinicians are unfamiliar with the Sinclair Method. Here's how to have a productive, informed conversation about naltrexone for alcohol use.

7 min readMarch 28, 2025

Science & Research

Why Willpower Alone Rarely Works for Alcohol

The science of alcohol dependence explains why 'just stop' is not a treatment plan — and what actually changes the brain's relationship with alcohol.

8 min readMarch 21, 2025

Science & Research

What Does the Research Actually Say About the Sinclair Method?

A plain-English look at the clinical evidence behind TSM, including the COMBINE study, Finnish trials, and real-world outcomes.

10 min readMarch 14, 2025

Science & Research

Alcohol and the Opioid System: Why Drinking Feels Good

Understanding why alcohol triggers the brain's reward system — and why blocking that response is the key mechanism behind the Sinclair Method.

8 min readMarch 7, 2025

Alcohol & BehaviorFeatured

How Much Is Too Much? Understanding Alcohol Use Disorder Criteria

The DSM-5 diagnostic criteria for alcohol use disorder explained in plain English — and why the spectrum matters more than any single label.

9 min readApril 28, 2025

Naltrexone

What Is Vivitrol? Injectable Naltrexone Explained

Vivitrol is the extended-release injectable form of naltrexone. Here's how it differs from oral naltrexone, who it's for, and what the research shows.

7 min readApril 21, 2025

Alcohol & Behavior

Alcohol and Anxiety: Why Drinking Worsens Anxiety Long-Term

Alcohol feels like it relieves anxiety — but the science shows it makes anxiety significantly worse over time. Here's why, and what helps.

9 min readApril 14, 2025

Educational Information Only

This site is for education only and is not a substitute for medical advice, diagnosis, or treatment. Always speak with a qualified, licensed clinician before making any decisions about medication or treatment. Naltrexone is a prescription medication and is not appropriate for everyone.